Interleukin-22: Immunobiology and Pathology

IL 22 ( interleukin 22 )

Interleukin-22 in kidney injury and regeneration.

Interleukins have become well-known regulators of innate and adaptive immunity-related tissue inflammation. Recently, IL-22 has gained a lot of interest for its unique functions in maintaining and regaining epithelial integrity. IL-22 is exclusively secreted by different immune cell subsets, while IL-22 receptors are mainly expressed by epithelial cells. As the kidney is largely an epithelial o...

IMMUNOBIOLOGY Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils

Interleukin-9 (IL-9) has been implicated in the pathogenesis of allergic disorders. To examine the interaction between IL-9 and eosinophils, we evaluated mature peripheral blood eosinophils for their expression of the specific a-subunit of the IL-9 receptor (IL-9R–a). The expression of IL-9R–a by human eosinophils was detected at the messenger RNA (mRNA) and protein levels by reverse transcript...

IMMUNOBIOLOGY Protein tyrosine phosphatase eC selectively inhibits interleukin-6– and interleukin- 10–induced JAK-STAT signaling

Protein tyrosine phosphatase (PTP) e (PTPe) exists as 2 forms generated by alternative promoter usage. It has recently been reported that a cytosolic isoform of PTPe (PTPeC) when over-expressed in murine M1 myeloid cells inhibits interleukin-6 (IL-6)– and leukemia inhibitory factor–induced activation of Janus kinsases (JAKs), thereby suppressing STAT3 tyrosine phosphorylation and STAT3 signalin...

Tristetraprolin regulation of interleukin-22 production

Interleukin (IL)-22 is a STAT3-activating cytokine displaying characteristic AU-rich elements (ARE) in the 3'-untranslated region (3'-UTR) of its mRNA. This architecture suggests gene regulation by modulation of mRNA stability. Since related cytokines undergo post-transcriptional regulation by ARE-binding tristetraprolin (TTP), the role of this destabilizing protein in IL-22 production was inve...